Decoding the complex blueprint of human health and diseases through the most ambitious and comprehensive multi-omics initiative in history.
Years of experience
The Global One Million Phenome Initiative (1M-PI) is a landmark global research initiative aimed at revolutionizing medicine by harnessing the power of large-scale multi-omics data from one million individuals. This diverse cohort comprises both healthy volunteers and patients affected by rare and complex diseases, including neurological, immunological, infectious, inflammatory, and respiratory conditions, as well as a broad spectrum of cancers. Additionally, the initiative includes individuals with prevalent metabolic disorders such as obesity, diabetes, hypertension, hyperinsulinemia, and dyslipidemia, offering an unparalleled resource for advancing precision health at scale.
The 1M-PI project is supported by a highly standardized framework that ensures data quality, consistency, and translational impact across diverse populations and disease contexts. It leverages:
The goal of the 1M-PI is to generate the world’s most extensive and demographically diverse multi-omics dataset, serving as a foundational resource to:
Realizing the promise of personalized medicine demands both unprecedented scale and deep biological diversity. Yet, most existing datasets remain limited—geographically restricted, ethnically narrow, constrained to single-omics layers, or focused on a narrow spectrum of diseases—thus impeding their global translational relevance using AI and Systems Biology.
The 1M-PI rises to this challenge by constructing the most expansive and inclusive multi-omics resource ever assembled. Through standardized protocols, it systematically collects high-dimensional data from globally distributed cohorts encompassing:
By bridging critical gaps in data representation, 1M-PI is positioned to transform fragmented biomedical research into a cohesive foundation for globally equitable, precision diagnostics and truly preventive healthcare.
Artificial Intelligence (AI), Systems Biology, and Big Biological Data to create a unified, multidimensional view of human health. This includes comprehensive multi-omics layers—genomics, transcriptomics, epigenomics, proteomics, metabolomics, lipidomics, and metagenomics—alongside clinical records, wearable device outputs, medical imaging, and detailed information on diet, medications, toxins, and other environmental exposures. By combining these diverse data streams, 1M-PI enables unprecedented insights into the complex interplay between biology, lifestyle, and environment—driving a new era of predictive, preventive, and personalized medicine.
Healthy Individuals
Patients
Patients diagnosed with select cancers, as well as neurological, immunological, infectious, inflammatory, rare, and respiratory disorders, alongside individuals affected by metabolic conditions such as obesity, diabetes, hypertension, hyperinsulinaemia, and dyslipidaemia, form a critical component of the 1M-PI cohort—ensuring broad disease representation across complex and prevalent health challenges.
At the heart of the 1M-PI lies a bold scientific vision: to construct a dynamic, continuously evolving health intelligence system that integrates the complexity of human biology with the power of AI and systems-level thinking.
High-quality, standardized multi-omics data are generated through our accredited laboratories located in the USA, Türkiye, and South Korea, with additional state-of-the-art facilities soon to be launched in the UK and India. These hubs form the backbone of a global infrastructure designed to deliver deep, reproducible insights into human health across diverse populations and ecosystems..
Our proprietary AI and Systems Biology platforms are designed to extract actionable insights from complex, high-dimensional data. By integrating multi-omics, clinical, and environmental inputs, these technologies enable us to
Our dedicated mobile application provides participants with a comprehensive and interactive platform to monitor their diet, wearable sensor data, and overall health metrics in real time. It also features interactive visualizations of individual multi-omics profiles and access to personalized clinical reports, enabling users to engage deeply with their biological data and track their health trajectories in a meaningful and informed way.
The 1M-PI brings together an international consortium of visionary scientists, clinicians, and technologists committed to transforming the future of healthcare.
The initiative is led by Professor Adil Mardinoglu—a globally recognized leader in systems biology and precision medicine—affiliated with King’s College London, KTH – Royal Institute of Technology, and Phenome Longevity Inc. USA
The 1M-PI brings together an international consortium of visionary scientists, clinicians, and technologists committed to transforming the future of healthcare.
The initiative is led by Professor Adil Mardinoglu—a globally recognized leader in systems biology and precision medicine—affiliated with King’s College London, KTH – Royal Institute of Technology, and Phenome Longevity Inc.
The centralized Phenome Portal, designed for secure data integration, analysis, and visualization, has been launched, providing real-time access to multi-omics insights.
The Phenome Atlas, a global platform for responsible data sharing and collaboration, will go live—accelerating discovery across institutions and disciplines.
More than 100,000 biological samples will be processed and analyzed using standardized multi-omics pipelines, generating one of the world’s richest biomedical datasets.
The initiative will reach its $100 million funding target, securing the financial foundation for global expansion, innovation, and long-term impact.
The 1M-PI is forging a new paradigm in healthcare—powered by science, scale, and global collaboration. We are actively seeking visionary partners who share our commitment to advancing precision health. Opportunities for collaboration include:
